Manchester United boss Louis van Gaal is desperate to register their first win of the season along with his summer recruits.
The Argentine defender Marcos Rojo has been granted a UK work permit and Luke Shaw is fully fit to be a part of the game to Old Trafford. The summer deadline signing Daley Blind and Radamel Falcao are also available for the encounter.
However, the Defensive midfielder Phil Jones has been ruled out of action for a month with a hamstring injury.
Queens Park Rangers manager Harry Redknapp could be without the services of Joey Barton after the 32-year-old midfielder picked up a minor injury while training session.
As a result, the Brazilian midfielder Sandro Raniere could make a debut, who has been brought in from Spurs from for £10 million.
The former United star Rio Ferdinand, who left the Red Devils to join the Hoops in the summer, will feature as centre-back.
Manchester United: LDLD
Queens Park Rangers: LLLW
Possible starting Lineups:
Man United: De Gea, Rojo, Blind, Evans, Di Maria, Fletcher, Shaw, Valencia, Mata, Van Persie, Rooney.
QPR: Green, Caulker, Hill, Isla, Ferdinand, Phillips, Mutch, Hoilett, Sandro, Fer, Austin.
Man United 3 – 0 QPR